The early diagnosis of diseases requires sensitive detection methods for biological molecules, known as biomarkers. This research focuses on the potential breakthrough offered by plasmonic nanoparticles, specifically silver-based nanoparticles. Unlike commonly used gold nanoparticles, these silver counterparts boast remarkably strong and sharp localized surface plasmon resonance (LSPR) absorbance, while with lower stability compared to gold. Therefore, this project involves the synthesis of hybrid, functionalized silver nanoparticles (AgNPs), varying their size and morphologies, and stabilizing them with a thin layer of gold. These gold-plated AgNPs possess the stability of gold while maintaining the superior LSPR of silver. The surfaces of the nanoparticles will be further functionalized with diverse polymeric and metal oxide layers. Rigorous testing of the stability of these nanostructures in different biological buffers and solutions, coupled with the evaluation of their impact on cell viability, forms a crucial aspect of the study. A significant milestone is the development of nanosensors utilizing these nanostructures, with a particular emphasis on evaluating their stability in diverse biological systems. The anticipated outcomes include not only optimizing the fabrication process for these nanosensors but also documenting the involvement and skill development of undergraduate students. This project paves the way for future projects that will use these developed nanosensors as customized immunosensors for early diagnosis of diverse cancer types. The findings from this research are expected to be disseminated through publications in high-impact journals and conference presentations, making a substantial contribution to the advancement of biosensing technologies and their potential applications in early disease detection.